Ardizzone is an Italian surname. Notable people with the surname include:
Edward Ardizzone (1900–1979), English artist, illustrator, and writer Francesco Ardizzone (born 1992), Italian soccer player Joseph Ardizzone (1884–1931), Italian–born American mobster Simon Ardizzone, American documentarian and producer Tony Ardizzone (born 1949), American writer Tony Ardizzone (American football) (born 1956), American football player