Kawaguchi (written: or lit. "river mouth") is a Japanese surname. Notable people with the surname include:
Ekai Kawaguchi (1866–1945), Japanese Buddhist monk Hiroshi Kawaguchi (composer) (born 1965), Japanese composer and keyboardist Junnosuke Kawaguchi (born 1961), Japanese bassist Kaiji Kawaguchi (born 1948), Japanese manga author Keiichiro Kawaguchi, Japanese animator and director Masafumi Kawaguchi (born 1973), Japanese player of American football Matsutarō Kawaguchi (1899–1985), Japanese writer Kiyotake Kawaguchi (1892–1961), Japanese general during World War II Senri Kawaguchi (born 1997), Japanese drummer Takao Kawaguchi (born 1950), Japanese judoka Yoichiro Kawaguchi (born 1952), Japanese computer graphics artist Yoriko Kawaguchi (born 1941), Japanese politician Yoshikatsu Kawaguchi (born 1975), Japanese footballer Yuko Kavaguti (born 1981), Japanese Russian pair skater Yutaka Kawaguchi (born 1973), Japanese ice hockey player Hiromu Kawaguchi (born 1962) Japanese Canadian karateka