Brest is a surname. Notable people with the surname include:
Harold Brest, 20th-century American prisoner Jorge Romero Brest (1905–1989), Argentine art critic and curator Lewis F. Brest (1842–1915), Union Army soldier Martin Brest (born 1951), American filmmaker, producer, screenwriter, film editor, and actor Paul Brest (born 1940), American academic Vida Brest (1925–1985), Slovenian poet and writer
Benjamin Issac Brest - Kansas