Whitson is a surname. Notable people with the surname include:
Beth Slater Whitson (1879–1930), American lyricist Ed Whitson (born 1955), American baseball player Frank Whitson (1877–1946), American film actor John Whitson (1558–1629), English merchant and politician Keith Whitson (born 1943), British banker Peggy Whitson (born 1960), American biochemist and astronaut Sam Whitson, American politician Tony Whitson (1885–1945), South African soccer player