Carboxybiotin decarboxylase (, MadB, carboxybiotin protein decarboxylase) is an enzyme with systematic name carboxybiotinyl-(protein) carboxy-lyase. This enzyme catalyses the following chemical reaction
a carboxybiotinyl-[protein] + n Na+in + H+out CO2 + a biotinyl-[protein] + n Na+out (n = 1--2)
This enzyme is an integral membrane protein MadB from the anaerobic bacterium Malonomonas rubra.
Nomenclature This enzyme was previously classified as .
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