Methanogen homoaconitase (, methanogen HACN) is an enzyme with systematic name (R)-2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate-forming). This enzyme catalyses the following chemical reaction
(R)-2-hydroxybutane-1,2,4-tricarboxylate (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate (overall reaction) (1a) (R)-2-hydroxybutane-1,2,4-tricarboxylate (Z)-but-1-ene-1,2,4-tricarboxylate + H2O (1b) (Z)-but-1-ene-1,2,4-tricarboxylate + H2O (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate
This enzyme catalyses several reactions in the pathway of coenzyme-B biosynthesis in methanogenic archaea.
References
External links