trans-o-Hydroxybenzylidenepyruvate hydratase-aldolase (, 2′-hydroxybenzalpyruvate aldolase, NsaE, tHBPA hydratase-aldolase) is an enzyme with systematic name (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate hydro-lyase. This enzyme catalyses the following chemical reaction

(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O salicylaldehyde + pyruvate

This enzyme is involved in naphthalene degradation.

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