Pyrrole-2-carboxylate decarboxylase () is an enzyme with systematic name pyrrole-2-carboxylate carboxy-lyase. This enzyme catalyses the following chemical reaction

(1) pyrrole-2-carboxylate pyrrole + CO2 (2) pyrrole-2-carboxylate + H2O pyrrole + HCO3−

The enzyme catalyses both the carboxylation and decarboxylation reactions.

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