Biotin-independent malonate decarboxylase (, malonate decarboxylase (without biotin), malonate decarboxylase, MDC) is an enzyme with systematic name malonate carboxy-lyase (biotin-independent). This enzyme catalyses the following chemical reaction
malonate + H+ acetate + CO2
Two types of malonate decarboxylase are currently known, both of which form multienzyme complexes.
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