Papathanasiou () is a Greek family name. People with this name include:
Evangelos Odysseas Papathanassiou, better known as Vangelis, musician Vassiliki Papathanasiou, better known as Vicky Leandros, singer Leandros Papathanasiou, better known as Leo Leandros, musician Aspasia Papathanasiou, Greek actress Andreas Papathanasiou (born 1983), Cypriot footballer Yannis Papathanasiou (born 1954), Greek politician Aimilios Papathanasiou (born 1973), Greek sailor