Diadenosine hexaphosphate hydrolase (AMP-forming) (, hAps1, NUDT11 (gene), hAps2, NUDT10 (gene)) is an enzyme with systematic name P1,P6-bis(5'-adenosyl)hexaphosphate nucleotidohydrolase (AMP-forming). This enzyme catalyses the following chemical reaction

(1) P1,P6-bis(5'-adenosyl)hexaphosphate + H2O adenosine 5'-pentaphosphate + AMP (2) P1,P5-bis(5'-adenosyl)pentaphosphate + H2O adenosine 5'-tetraphosphate + AMP

A divalent cation is essential for activity.

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