First Interstate Center may refer to:

First Interstate Center, in Billings, Montana, United States, operated by the First Interstate BancSystem First Interstate Center (Missoula, Montana), U.S. First Interstate Center for the Arts, a theatre in Spokane, Washington

It may also refer to buildings of First Interstate BancSystem's predecessor, the former First Interstate Bancorp:

Wells Fargo Center (Portland, Oregon), formerly named First Interstate Tower or First Interstate Center Wells Fargo Center (Seattle), formerly named First Interstate Center

See also First Interstate Tower (disambiguation)