L-proline amide hydrolase (, S-stereoselective piperazine-2-tert-butylcarboxamide hydrolase, LaaA, L-amino acid amidase) is an enzyme with systematic name (S)-piperidine-2-carboxamide amidohydrolase. It catalyses several related hydrolysis reactions.
For example, prolinamide is converted to proline:
The enzyme characterised from Pseudomonas azotoformans also gives (-)-pipecolic acid from (S)-piperidine-2-carboxamide:
An X-ray structure of the enzyme showed it to be similar to prolyl aminopeptidase.
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