ADAMTS-4 endopeptidase (, aggrecanase-1) is an enzyme. This enzyme catalyses the following chemical reaction

Glutamyl endopeptidase; bonds cleaved include -Thr-Glu-Gly-Glu373-Ala-Arg-Gly-Ser- in the interglobular domain of mammalian aggrecan

This enzyme belongs to the peptidase family M12.

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