Afandiyev (masculine, ) or Afandiyeva (feminine, ) is an Azerbaijani surname. Notable people with the surname include:
Elchin Afandiyev (1943–2025), Azerbaijani writer, academic and politician Ilyas Afandiyev (1914–1996), Azerbaijani Soviet writer Sultan Majid Afandiyev (1887–1938), Azerbaijani revolutionary and politician Narmin Afandiyeva (born 1993), Azerbaijani chemist