Afamasaga is both a given name and a surname. Notable people with the name include:

Afamasaga Rico Tupai (born 1969), Samoan politician Failaga Afamasaga (born 1989), Samoan rugby union player Gatoloai Tili Afamasaga (born 1947), Samoan educator Jack Afamasaga (born 1984), New Zealand rugby player