Gayne is a surname. Notable people with the surname include:
Chris Gayne, Scottish sound designer Gayne Dexter (1895–1966), Australian journalist, publicist and screenwriter Gayne Rescher, (1924–2008), American cinematographer Gayne Whitman (1890–1958), American radio and film actor
See also Gaine, surname Gayane (disambiguation) Gaynes (disambiguation)