Trimerelysin II (, Trimeresurus metalloendopeptidase II, proteinase H2, H2-proteinase) is an enzyme. This enzyme catalyses the following chemical reaction
Cleavage of Asn3-Gln, His10-Leu and Ala14-Leu in the insulin B chain, and the bond Z-Gly-Pro-Leu-Gly-Pro in a small molecule substrate of microbial collagenase
This endopeptidase is present in the venom of the habu snake (Trimeresurus flavoviridis).
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