Bothropasin (, Bothrops jararaca venom metalloproteinase) is an enzyme. This enzyme catalyses the following chemical reaction

Cleavage of His5-Leu, His10-Leu, Ala14-Leu, Tyr16-Leu and Phe24-Phe in insulin B chain

This endopeptidase is present in the venom of jararaca snake (Bothrops jararaca).

See also Atrolysin A

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