Plasmepsin I (, aspartic hemoglobinase I, PFAPG, malaria aspartic hemoglobinase) is an enzyme. This enzyme catalyses the following chemical reaction

Hydrolysis of the -Phe33-Leu- bond in the alpha-chain of hemoglobin, leading to denaturation of the molecule

This enzyme is present in the malaria organism, Plasmodium.

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