GSR may refer to:
Law General Statutory Rules
Medicine, science and technology Galvanic skin response, physiological phenomenon Glutathione-disulfide reductase, enzyme Gunshot residue
Organizations Gas Safe Register, in the United Kingdom Global Sea Mineral Resources, an underwater mining company Groupe Scolaire La Résidence, a French international school in Casablanca, Morocco
Places Gerber Scout Reservation, a scouting facility in Michigan, U.S. Postal code for Għasri, Gozo Island, Malta Grand Sierra Resort, a hotel and casino in Nevada, U.S.
Transport Acura Integra GS-R, an automobile IATA code for Qardho Airport, Somalia
Rail systems Great Southern Railway (disambiguation) Great Southern Railways, a former Irish railway company Gondal State Railway, in British India Great Sandhills Railway, a Canadian railway
Other uses Greenville Swamp Rabbits Grammata Serica Recensa, a dictionary of Old Chinese General Service Respirator, a military gas mask SIG Sauer GSR, a pistol variety