Izzo is an Italian surname. Notable people with the surname include:
Angelo Izzo, Italian pharmacologist Armando Izzo (born 1992), Italian footballer Jean-Claude Izzo (1945–2000), French poet, playwright, screenwriter, and novelist John Izzo, American and Canadian businessman, corporate advisor, speaker, bestselling author and an advocate for sustainable living Larry Izzo (born 1974), American football player Lorenza Izzo (born 1989), Chilean film actress and model Paul Izzo (born 1995), Australian professional football player Renato Izzo (1929-2009), Italian actor, voice actor and screenwriter Ryan Izzo (born 1995), American football player Simona Izzo (born 1953), Italian actress, voice actress, director and screenwriter Tom Izzo (born 1955), American college basketball coach