The 1980–81 Macedonian Republic League was the 37th since its establishment. FK Pobeda won their 7th championship title.
Participating teams Club City 11 Oktomvri Prilep Belasica Strumica Borec Titov Veles Bregalnica Shtip Kozhuf Gevgelija Ljuboten Tetovo Metalurg Skopje Napredok Kichevo Pelister Bitola Pobeda Prilep Prilep Pobeda Valandovo Valandovo Sasa Makedonska Kamenica Sloga Vinica Tikvesh Kavadarci Vardar Negotino Vardarski Bogdanci
Final table
External links SportSport.ba Football Federation of Macedonia