Limulus clotting factor B () is an enzyme. This enzyme catalyses the following chemical reaction:
Selective cleavage of -Arg98-Ile99- bond in limulus proclotting enzyme to form active clotting enzyme
This enzyme is present in the hemocyte granules of the horseshoe crabs Limulus and Tachypleus. In the immunity-related clotting pathways of these organisms, factor B is downstream of Limulus clotting factor C, but upstream of Limulus clotting enzyme.
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