Humberstone or Humberston is a surname. Notable people with the surname include:
Arthur Humberstone (1912–1999), British animator Chris Humberstone (1946–1999), English automobile designer Clara E. Speight-Humberston (1862-1936), Canadian research scientist and scientific writer H. Bruce Humberstone (1901–1984), American screen actor and film director Holly Humberstone (born 1999), English singer-songwriter James Thomas Humberstone (1850–1939), English chemical engineer Simon Humberstone (born 1987), British rugby Union player William Humberstone (1836–1922), Canadian politician William Humberstone (Leicester MP) (), English Member of Parliament