Heflin is a surname. Notable people with the surname include:
Clarence Heflin (1921–2007), American politician from Missouri Donald Heflin (born 1958), American diplomat and ambassador Frances Heflin (1920–1994), American actress Howell Heflin (1921–2005), American politician from Alabama Jack Heflin (born 1998), American football player James Thomas Heflin (1869–1951), American politician from Alabama
Van Heflin (1910–1971), American actor Victor Heflin (born 1960), American football player