Holcombe is a surname, originating in a number of English villages with the name. Early examples are recorded as de Holcombe, and the final e has been dropped from many family names. Notable people with the surname Holcombe (with an e) include:

Alex Holcombe (born 1969), American basketball player Brett Holcombe, Australian paralympic athlete Brian Holcombe (born 1941), former Australian Rules footballer Carven Holcombe (born 1964), American basketball player Ken Holcombe (1918–2010), Major League Baseball pitcher Randall G. Holcombe (born 1950), American economist

See also Holcomb (surname)