Metallocarboxypeptidase D (), often just called Carboxypeptidase D, is an enzyme that in humans is encoded by the CPD gene. This enzyme catalyses the following chemical reaction
Releases C-terminal Arg and Lys from polypeptides
This enzyme is activated by Co2+, and inhibited by guanidinoethylmercaptosuccinic acid.
Function
The metallocarboxypeptidase family of enzymes is divided into 2 subfamilies based on sequence similarities: the pancreatic carboxypeptidase-like and the regulatory B-type carboxypeptidase subfamilies. Carboxypeptidase D has been identified as a regulatory B-type carboxypeptidase. CPD is a homolog of duck gp180, a hepatitis B virus binding protein. Transcript variants utilizing alternative polyadenylation signals exist for this gene.
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