Heffron is a surname. Notable people with the surname include:
Bob Heffron (1890–1978), Australian politician Brian Heffron (born 1973), wrestler and actor Edward Heffron (1923–2013), paratrooper Frank Heffron (1936–2023), American politician John Heffron, comic Mark Heffron, boxer Patrick Richard Heffron (1860–1927), bishop Richard T. Heffron (1930–2007), director Dennis (Denis) Heffron (1950-2020) United States Marine in Vietnam War Sean J. Heffron (1976-2023) Hip Hop Artist