Puccio is both an Italian surname and a masculine Italian given name. Notable people with the name include:

People with the surname Alejandro Puccio (1958–2008), Argentine rugby union footballer and criminal Alessio Puccio (born 1986), Italian voice actor Alex Puccio (born 1989), American rock climber Carlos López Puccio (born 1946), Argentinian musician Gabriele Puccio (born 1989), Italian footballer Gary Puccio, American college baseball coach Marty Puccio (born 1973), American murderer Nicola Puccio (born 1971), Australian born Italian cricketer Puccio family, Argentinian crime family Salvatore Puccio (born 1989), Italian cyclist Thomas Puccio (1944–2012), American trial attorney Val Puccio (1965–2011), American wrestler Vincenzo Puccio (1945–1989), Sicilian mafioso

People with the given name Puccio Capanna, Italian painter Puccio Pucci (lawyer) (1904–1985), Italian lawyer and sports official Puccio Pucci (politician) (1389–1449), Florence Puccio di Simone (fl. 1346–1358), Italian Gothic painter