Merle is a surname. Notable people with the surname include:
Carole Merle (born 1964), French former alpine skier Foulques du Merle (died 1314), Marshal of France Frank Merle (mathematician) (born 1962), French mathematician Georges Merle (1851–1886), French painter Guy du Merle (1908–1993), French aeronautical engineer, test pilot and writer Hugues Merle (1823–1881), French painter; father of Georges Merle Leo Merle (born 1998), American Paralympic athlete Matthieu Merle (c. 1548 – after 1587), Huguenot captain in the Wars of Religion Natasha C. Merle (born 1983), American lawyer and judge Olivier Merle (born 1965), French former rugby union footballer Pierre Hugues Victoire Merle (1766–1830), French general of the Napoleonic Wars Robert Merle (1908–2004), French novelist