Ruff is a surname. Notable people with the surname include:
Alex Ruff (born 1974), Canadian politician Bálint Ruff, Hungarian politician Charles Ruff (1939–2000), American lawyer Guy Ruff (born 1960), American football player Howard Ruff, American financial adviser Jason Ruff (born 1970), Canadian hockey player Leon Ruff (born 1996), American professional wrestler Lindy Ruff (born 1960), Canadian hockey coach Matt Ruff (born 1965), American author Michelle Ruff (born 1967), American voice actress Otto Ruff (1871–1939), German chemist Thomas Ruff (born 1958), German photographer Willie Ruff (1931–2023), American hornist and bassist