Guppy is a surname. Notable people with the surname include:
People Darius Guppy (born 1964), insurance fraudster Eileen Guppy (1903–1980), British geologist Elisabeth Guppy (1838–1917), British spiritualist medium Henry B. Guppy (1854–1926), British botanist Henry Guppy (librarian) (1861–1948), British librarian John Guppy (politician) (1874–1937), fisherman, farmer and political figure in Newfoundland John Guppy (businessman), British businessman Lechmere Guppy (1836–1916), British naturalist; discoverer and namesake of the fish Sarah Guppy (1770–1852), British inventor Shusha Guppy (1935–2008), author, editor, singer and filmmaker Steve Guppy (born 1969), English retired footballer Wayne Guppy (born 1954), New Zealand politician
Fictional characters Mr (William) Guppy, from the novel Bleak House