Geffen (, lit. Grapevine) is a Hebrew surname. Notable people with the surname include:
Aviv Geffen (born 1973), Israeli rock singer David Geffen (born 1943), American record executive, film producer and theatrical producer Jeremy Geffen (1977–2018), American entrepreneur and entertainment executive Maxwell M. Geffen (1896–1980), American editor and publisher from New York Shira Geffen (born 1971), Israeli actress, screenwriter and film director Tobias Geffen (1870–1970), American rabbi from Atlanta, Georgia Yehonatan Geffen (1947–2023), Israeli writer Yetta Dorothea Geffen (1891–1986), American musician, journalist, and theatre professional