Messina is an Italian surname, originating from the city of Messina. Notable people with the surname include:
Messina Brothers, English crime gang Alessandro Messina (born 1969), Italian economist Alessandro Messina (cyclist) (1941–2022), Canadian cyclist from the 1960 Summer Olympics Antonello da Messina (c.1430–1479), Sicilian Renaissance painter Cedric Messina (c.1920-1993), British television producer and director Charles Messina (born 1971), American playwright, screenwriter and director Chris Messina (born 1974), American actor and film director Chris Messina (open source advocate) (born 1981), American technology evangelist Daniele Messina (born 1992), Italian footballer David Messina (born 1974), Italian comics artist Domenico Messina (born 1962), Italian Football referee Ettore Messina (born 1959), Italian basketball coach Fabian Messina (born 2002), Dominican Republic footballer Francesco Messina (1900–1995), Italian sculptor Frank Messina (born 1968), American poet, author and performance artist Gaspare Messina (1879–1957), founder of the Patriarca crime family Geofforoy Messina (born 1982), French rugby union footballer Gerlandino Messina (born 1972), Sicilian Mafia member Gina Messina Dysert (born 1975), American activist Giuseppe Messina (born 1993), Italian footballer Guido Messina (1931–2020), Italian road bicycle and track cyclist Ignazio Messina (born 1964), Italian politician Jack Messina (born 2007), American actor Jim Messina (musician) (born 1947), American rock musician and producer Jim Messina (political staffer) (born 1969), American political adviser Jo Dee Messina (born 1970), American country music artist Joe Messina (1928–2022), American guitarist Leonardo Messina (born 1955), member of the Sicilian Mafia turned government informant Maria Messina (1887–1944), Italian writer Matteo Messina Denaro (1962-2023), Sicilian Mafia member and fugitive Michelangelo Messina, founder and artistic director of the Ischia Film Festival Sal Messina (born 1939), American ice hockey commentator Tony Messina, American chef