Grillo is an Italian surname. Notable people with the surname include:
Angelo Grillo (1557–1629), Italian poet and lyricist who wrote madrigals for Claudio Monteverdi Antonio Grillo (footballer, born 1986), Italian football defender Antonio Grillo (footballer, born 1991), Italian football defender Beppe Grillo (born 1948), Italian comedian and politician Casey Grillo (1997–2018), American drummer Chuck Grillo (born 1939), American professional ice hockey executive Elisabetta and Francesca Grillo, defendants in R v Grillo and Grillo Emiliano Grillo (born 1992), Argentine professional golfer Ernesto Grillo (1929–1998), Argentine football player Frank Grillo (born 1965), American actor Friedrich Grillo (1825–1888), German industrialist Gabriela Grillo (1952–2024), German equestrian and businesswoman Giovanni Battista Grillo, Venetian composer and organist (late 16th century–mid-November 1622) Janet Grillo, American filmmaker and screenwriter Leo Grillo (born 1948), American film actor, producer and animal welfare activist Manuela Grillo (born 1977), Italian sprinter Natasha Grillo (born 1995), Italian professional racing cyclist Niccolò Grillo, Italian composer Odhise Grillo (1932–2003), Albanian writer of children's books Paride Grillo (born 1982), Italian cyclist Roger Grillo (born 1964), American ice hockey player and coach Santiago Grillo, Colombian windsurfer Tyran Grillo, Japanese writer and translator Ulrich Grillo (born 1959), German entrepreneur and former president of the Federation of German Industries (BDI)
Yusuf Grillo (1934–2021), Nigerian painter
Fictional characters: Jack Grillo, video game character
See also Javier Grillo-Marxuach, television screenwriter and producer