Powell Creek, Powells Creek or Powell's Creek may refer to:
In Australia Powells Creek (Sydney), a tributary of the Parramatta River in New South Wales
In the United States Powell Creek, West Virginia, an unincorporated community in Boone County Powells Creek (Hyco River tributary), a stream in North Carolina and Virginia Powell Creek (Pennsylvania), a tributary of the Susquehanna River in Dauphin County Powell's Creek (James River tributary), a stream in Virginia Powells Creek (Potomac River tributary), a stream in Virginia