Intermediate cleaving peptidase 55 (, Icp55, mitochondrial intermediate cleaving peptidase 55 kDa) is an enzyme. This enzyme catalyses the following chemical reaction

The enzyme cleaves the Pro36-Pro37 bond of cysteine desulfurase (EC 2.8.1.7) removing three amino acid residues (Tyr-Ser-Pro) from the N-terminus after cleavage by mitochondrial processing peptidase.

Icp55 removes the destabilizing N-terminal amino acid residues.

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