Fantini is an Italian surname. Notable people with the surname include:
Ascensidonio Spacca (ca. 1557 – 1646), known as Fantini, Italian painter Akira Fantini (born 1998), Japanese footballer Alessandro Fantini (1932–1961), Italian cyclist Corrado Fantini (born 1967), Italian shot putter Enrico Fantini (born 1976), Italian footballer Marco Fantini (born 1965), Italian artist Nicholas Fantini (born 1984), real name of Italian rapper Egreen