Nessus may refer to:
Mythology Nessus (mythology), multiple figures from Greek mythology, including: Nessus (centaur), a centaur who caused the death of Heracles
Fiction Nessus (Pierson's Puppeteer), an alien character in Larry Niven's Known Space books Nessus, a fictional metropolis in Gene Wolfe's The Book of the New Sun Nessus, a layer of Hell (Baator) in the Dungeons & Dragons tabletop game Nessus, one of the moons of the fictional planet Chiron in the computer game Sid Meier's Alpha Centauri Nessus, a planetoid location in the video game Destiny 2, based on the below Centaur
Science and technology 7066 Nessus, a Centaur planetoid Nessus (software), a computer security tool Nessus (Blackberry), the proprietary kernel all Blackberry before BlackBerry 10 were based upon NESSUS Probabilistic Analysis Software, a tool for assessing uncertainties in structural and mechanical systems Nessus sphinx or Amphion floridensis, a moth found in North America
Other uses , two vessels of the Royal Navy (UK)