Isom may refer to:
Places Isom, Kentucky, an unincorporated community in Letcher County Isom, Virginia, an unincorporated community in Dickenson County Isom, West Virginia, an unincorporated community in Logan County Lake Isom, a lake in Lake County, Tennessee
People Isom (surname) Isom Dart (1849-1900), American rodeo clown and stunt rider, rancher, and horse and cattle rustler
Other Isom, a comic book by Cliff Richards and Eric July ISO base media file format USS William Isom (ID-1555), a United States Navy tanker