(ADP-ribosyl)hydrolase 1, also termed [Protein ADP-ribosylarginine] hydrolase and protein-Nω-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase (), is an enzyme that in humans is encoded by the ADPRH gene. This enzyme is a specific mono(ADP-ribosyl)hydrolase that catalyses the removal of an ADP-ribosyl modification from target arginine residues of protein substrates. The chemical reactions can formally be described as follows:
Nω-(ADP-D-ribosyl)-L-arginyl-[protein] + H2O ADP-D-ribose + L-arginyl-[protein] In addition, the enzyme can reverse the ADP-ribosylation of free arginine: Nω-(ADP-D-ribosyl)-L-arginine + H2O ADP-D-ribose + L-arginine
See also ADP-ribosylhydrolase
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