de Lillo is a surname. Notable people with the surname include:
Domenico De Lillo (born 1937), Italian cyclist Don DeLillo (born 1936), American writer and playwright Ginés de Lillo (1566–1630), Spanish soldier
See also Puebla de Lillo, municipality in the province of León, Castile and León, Spain San Miguel de Lillo, church in Asturias, Spain