Glucan 1,6-α-glucosidase (, exo-1,6-β-glucosidase, glucodextrinase, glucan α-1,6-D-glucohydrolase) is an enzyme with systematic name glucan 6-α-D-glucohydrolase. It catalyses the hydrolysis of (1→6)-α-D-glucosidic linkages in (1→6)-α-D-glucans and derived oligosaccharides

Hydrolysis is accompanied by inversion at C-1, so that new reducing ends are released in the β-configuration.

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