This is a list of films which have placed number one at the weekend box office in Spain during 2010.

Number-one films †This implies the highest-grossing movie of the year. # Date Film Gross in euros Gross in US dollars Notes 1 Avatar €6,705,312 $9,649,320 It was Avatar'''s third week at number one. |- | 2 || || €4,650,728 || $6,704,235 ||Avatar became the highest-grossing film in Spain of all time. |- | 3 || || €4,342,660 || $6,249,331 || |- | 4 || || €3,994,297 || $5,648,045 || |- | 5 || || €3,641,889 || $5,050,393 || |- | 6 || || €3,037,379|| $4,156,182 || |- | 7 || || €2,343,026 || $3,195,398 || |- | 8 || || rowspan="2" |Shutter Island|| €2,438,309 || $3,320,228 || |- | 9 || || €1,625,337 || $2,215,926 || |- | 10 || ||The Men Who Stare at Goats|| €1,354,341 || $1,846,007 || |- | 11 || || Green Zone || €1,117,164 || $1,538,751 || |- | 12 || || The Book of Eli || €1,377,132 || $1,864,214 || |- | 13 || || How to Train Your Dragon || €1,787,792 || $2,394,033 || |- | 14 || || rowspan="2" | Clash of the Titans || €4,121,454 || $5,565,171 || |- | 15 || || €1,678,598|| $2,266,875 || |- | 16 || || rowspan="4" | Alice in Wonderland|| €7,613,995 || $10,283,762 || Alice in Wonderland had the highest weekend debut of 2010. |- | 17 || || €4,225,262 || $5,655,096 || |- | 18 || || €2,759,010 || $3,668,214 || |- | 19 || || €1,835,074 || $2,342,000 || |- | 20 || || Robin Hood || €3,619,396 || $4,475,075 || |- | 21 || || rowspan="2" | Prince of Persia: The Sands of Time || €2,400,479 || $3,019,433 || |- | 22 || || €1,641,834 ||$2,015,856 || |- | 23 || || Sex and the City 2 || €1,460,892 || $1,749,089 || |- | 24 || || Prince of Persia: The Sands of Time || €955,268 || $1,157,480 || Prince of Persia: The Sands of Time reclaimed #1 in its fourth weekend of release. |- | 25 || || rowspan="2" | Marmaduke || €722,937 || $894,447 || Marmaduke had the lowest number-one weekend debut of 2010. |- | 26 || || €502,723 || $622,090 || The second weekend of Marmaduke had the lowest number-one weekend of 2010. |- | 27 || || The Twilight Saga: Eclipse || €5,260,905 || $6,613,497 || |- | 28 || || rowspan="2" | Shrek Forever After || €3,249,149 || $4,108,634 || |- | 29 || || €3,385,900 || $4,379,641 || |- | 30 || || rowspan="2" style="background-color:#FFFF99" | Toy Story 3 † || €4,049,875 || $5,230,639 || |- | 31 || || €2,789,135 || $3,641,358 || |- | 32 || || rowspan="2" |Inception || €3,402,776 || $4,520,400 || |- | 33 || || €2,190,265 || $2,794,561 || |- | 34 || || Salt || €1,941,164 ||$2,468,292 || |- | 35 || || The Karate Kid || €2,993,255 || $3,821,827 || |- | 36 || || The Sorcerer's Apprentice || €1,712,757 || $2,209,553 || |- | 37 || || Resident Evil: Afterlife || €2,651,992 || $3,364,447 || |- | 38 || || The American || €1,200,073 || $1,566,757 || |- | 39 || || Eat Pray Love || €1,493,574 || $2,015,891 || |- | 40 || || Vampires Suck || €1,114,715 || $1,537,856 || |- | 41 || || rowspan="3" | Despicable Me || €2,467,220 || $3,439,976 || |- | 42 || || €1,603,187 || $2,241,592 || |- | 43 || || €961,387 || $1,342,176 || |- | 44 || || rowspan="2" | Los ojos de Julia || €1,601,321 || $2,234,142 || |- | 45 || || €1,119,884 || $1,571,922 || |- | 46 || || Unstoppable || €1,157,502 || $1,585,272 || |- | 47 || || rowspan="2" | Harry Potter and the Deathly Hallows – Part 1 || €5,898,426 || $8,067,768 || |- | 48 || || €2,759,993 || $3,656,104 || |- | 49 || || rowspan="2" | The Chronicles of Narnia: The Voyage of the Dawn Treader || €2,141,435 || $2,874,139 || |- | 50 || ||€1,662,550 || $2,199,839 || |- | 51 || || Tron: Legacy || €1,252,788 || $1,652,886 || |- | 52 || || Little Fockers'' €1,976,127 $2,594,091

Highest-grossing films + Highest-grossing films of 2010RankTitleDistributorDirector(s)ReleaseCountryDomestic Gross 1. Toy Story 3 Disney Lee Unkrich United States $33,154,762 2. Alice in Wonderland Disney Tim Burton United States $28,769,165 3. The Twilight Saga: Eclipse Aurum David Slade United States $25,050,394 4. Inception Warner Bros. Christopher Nolan United KingdomUnited States $22,212,764 5. Shrek Forever After Paramount Mike Mitchell United States $21,928,719 6. Harry Potter and the Deathly Hallows – Part 1 Warner Bros. David Yates United KingdomUnited States $19,017,186 7. The King's Speech DeAPlaneta Tom Hooper United Kingdom $15,863,460 8. The Chronicles of Narnia: The Voyage of the Dawn Treader Fox Michael Apted United KingdomUnited States $14,992,713 9. Clash of the Titans Warner Bros. Louis Leterrier United StatesUnited Kingdom $14,556,322 10. Despicable Me Universal Pierre Coffin & Chris Renaud United States $14,257,017

See also List of Spanish films — Spanish films by year

References