Sclareol cyclase (, geranylgeranyl pyrophosphate:sclareol cyclase, geranylgeranyl pyrophosphate-sclareol cyclase, GGPP:sclareol cyclase) is an enzyme with systematic name geranylgeranyl-diphosphate diphosphohydrolase (sclareol-forming). This enzyme catalyses the following chemical reaction

geranylgeranyl diphosphate + 2 H2O sclareol + diphosphate

This enzyme requires Mg2+ or Mn2+ for activity.

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