The enzyme 1,4-dihydroxy-2-naphthoyl-CoA hydrolase (EC 3.1.2.28; systematic name 1,4-dihydroxy-2-naphthoyl-CoA hydrolase) catalyses the following reaction:
The enzyme characterised from plants including Rubia tinctorum hydrolyses 1,4-dihydroxy-2-naphthoyl-CoA to coenzyme A and 1,4-dihydroxy-2-naphthoic acid (1), which form the thioester in the starting material.
This enzyme participates in the biosynthesis of juglone, , and several plant pigments. Its structure contains a HotDog domain.
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