de Soto is a Spanish surname. Notable people with the surname include:
Alexander de Soto (1840–1936), Spanish-American physician, businessman, and philanthropist Álvaro de Soto (born 1943), Peruvian diplomat and UN envoy Benito de Soto (1805–1830), pirate Domingo de Soto (1494–1560), Spanish theologian Ernest de Soto (1923–2014), American printmaker and lithographer Ernestine Ygnacio-De Soto, Barbareño Chumash activist and historian Francisco de Soto (), Spanish organist and composer Hernando de Soto (), Spanish conquistador Hernando de Soto Polar (born 1941), Peruvian economist and author Jesús Huerta de Soto (born 1956), economist, born in Spain Luis Barahona de Soto (1548–1595), Spanish poet Pedro de Soto (1493–1563), Spanish theologian