Otothyrinae is a subfamily of South American catfishes of the family Loricariidae.Chiachio, M.C., Oliveira, C. & Montoya-Burgos, J.I. (2008): Molecular systematic and historical biogeography of the armored Neotropical catfishes Hypoptopomatinae and Neoplecostominae (Siluriformes: Loricariidae). Molecular Phylogenetics and Evolution, 49 (2): 606-617. Alternatively it is treated as a tribe in Hypoptopomatinae.
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