2-phospho-L-lactate transferase (, LPPG:Fo 2-phospho-L-lactate transferase, LPPG:7,8-didemethyl-8-hydroxy-5-deazariboflavin 2-phospho-L-lactate transferase, MJ1256, lactyl-2-diphospho-(5')guanosine:Fo 2-phospho-L-lactate transferase, CofD) is an enzyme with systematic name (2S)-lactyl-2-diphospho-5'-guanosine:7,8-didemethyl-8-hydroxy-5-deazariboflavin 2-phospho-L-lactate transferase. It catalyses the following chemical reaction
The enzyme characterised from Methanococcus jannaschii uses (2S)-lactyl-2-diphospho-5'-guanosine to link the terminal hydroxy group of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (1) through a phosphate ester to a lactic acid. Guanosine monophosphate (GMP) is a byproduct. This reaction is part of the biosynthesis of coenzyme F420. The enzyme is also present in Paraburkholderia rhizoxinica and many other bacteria and archaea.
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